منابع مشابه
T cell CRAC dependence
A deadly receptor reveals a benevolent side in a study on page 575. Landau and colleagues show that the cell death–inducing receptor Fas is required for protection against neurodegeneration in a mouse model of Parkinson’s disease (PD). The Fas receptor (Fas), best known for its apoptotic role in the immune system, is widely expressed in nonimmune tissues, including the central nervous system. I...
متن کاملTRP Is Cracked but Is CRAC TRP?
fly's compound eye. Unlike many genetically identified proteins in this system, which are enzymes in the phos-Mayo Foundation Rochester, Minnesota 55905 phatidylinositol pathway, TRP and TRPL were originally presumed to be ion channels based on their putative It takes only one close look at a housefly to tell you six transmembrane-spanning topology and the phenotype of the associated trp mutant...
متن کاملMolecular basis of the CRAC channel.
Ca(2+) release-activated Ca(2+) (CRAC) channels, located in the plasma membrane, are opened upon release of Ca(2+) from intracellular stores, permitting Ca(2+) entry and sustained [Ca(2+)](i) signaling that replenishes the store in numerous cell types. This mechanism is particularly important in T lymphocytes of the immune system, providing the missing link in the signal transduction cascade th...
متن کامل(CRAC) Channels in Human T Cells
Although the crucial role of Ca 2 1 influx in lymphocyte activation has been well documented, little is known about the properties or expression levels of Ca 2 1 channels in normal human T lymphocytes. The use of Na 1 as the permeant ion in divalent-free solution permitted Ca 2 1 release-activated Ca 2 1 (CRAC) channel activation, kinetic properties, and functional expression levels to be inves...
متن کاملDatabase Cracking
Database indices provide a non-discriminative navigational infrastructure to localize tuples of interest. Their maintenance cost is taken during database updates. In this work we study the complementary approach, addressing index maintenance as part of query processing using continuous physical reorganization, i.e., cracking the database into manageable pieces. Each query is interpreted not onl...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2010
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb0510-416